Health communication stands at a transformative juncture, shaped by rapid technological evolution, persistent global health disparities, and a deepening recognition that effective health promotion demands more than information dissemination. This issue brings together fourteen cutting-edge contributions, including a review of the work of twelve leading scholars and three independent research articles. This collection traces a coherent arc from theoretical innovation to pragmatic intervention, illuminating how communication can bridge the gaps between policy and practice, technology and humanity, global frameworks and local realities. Representing diverse geographical and intellectual traditions—from Singapore to South Africa, from the Netherlands to New Zealand—these contributions underscore the field’s maturation into a truly global, multidisciplinary enterprise.

This issue of the Journal of Medicine, Humanity and Media (Vol. 3, No. 4) brings together selected papers from the 8th International Conference on “Medicine, Humanity and Media” (MHM 2025) & Doctoral Symposium, along with regular submissions addressing emerging topics in digital health communication, artificial intelligence, and cultural perspectives on well-being. Centered on the theme “Health Communication and Cultural Construction in the Age of Intelligence,” this collection reflects the field’s deepening engagement with technology, culture, and global health contexts, while highlighting the integration of humanistic reflection with computational innovation.

This issue of Journal of Medicine, Humanity and Media (Vol. 3, No. 3) centers on the theme of "Reconstructing the Knowledge System of Health Communication in the Digital Intelligence Era," which is also the core topic of the 8th International Conference on "Medicine, Humanity and Media" (MHM2025) and the Doctoral Forum. This issue presents curated content from the conference, focusing on paradigm shifts and ethical challenges in health communication amid technological advancements. In the current era of rapid digital development, the importance of effectively constructing and applying knowledge systems in health communication has become increasingly evident. How to leverage technological advantages to enhance communication efficacy while addressing the issues brought by technology and ensuring human-centered health communication has become a key concern for researchers.